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September 10, 2018

Ovarian Cancer Cells Retain Iron to Fuel Growth, Research Suggests

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Iron accumulation, a well-known feature of ovarian cancer cells, may play a role in cancer progression by increasing fatty acid metabolism, researchers at UConn Health suggest. Their study, “A Systems Biology Approach to ... Read more

September 7, 2018

Sorafenib plus Hycamtin Combo Prolongs Survival in Platinum-resistant Ovarian Cancer, Phase 2 Trial Shows

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Adding sorafenib, an anti-cancer oral medicine, to Hycamtin (topotecan) chemotherapy slows the time to disease progression or death in women with platinum-resistant ovarian cancer, a Phase 2 trial shows. The ... Read more

September 5, 2018

Algorithm Predicts Response to Measles Virus Therapy in Ovarian, Other Cancers, Study Shows

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Researchers at the Mayo Clinic developed an algorithm to predict the response of ovarian cancer patients to measles virus therapy, an investigational anti-cancer treatment being developed by the large U.S.-based medical ... Read more

August 29, 2018August 29, 2018

FDA OKs Phase 2 Trial Evaluating 2X-121 in Advanced Ovarian Cancer Patients

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The U.S. Food and Drug Administration has green-lighted a Phase 2 clinical trial that will assess the safety and effectiveness of the small molecule 2X-121 in advanced ovarian cancer patients, Oncology Venture has ... Read more

August 22, 2018August 22, 2018

Aravive Biologics’ Therapy Earns FDA’s Fast Track Designation to Treat Advanced Ovarian Cancer

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The U.S. Food and Drug Administration (FDA) has granted fast track designation to AVB-S6-500 as a potential therapy for chemotherapy-resistant ovarian cancer, Aravive Biologics, the therapy’s developer, announced. Fast track designation is given ... Read more

August 17, 2018August 19, 2018

Silencing GULP1 Gene Aids Ovarian Cancer Progression, Study Suggests

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Epigenetic silencing of the GULP1 gene is key for ovarian cancer progression, suggesting it could be used as a prognostic biomarker for the disease, a study found. The study, “Integrated transcriptomic and epigenomic analysis ... Read more

August 13, 2018

Phase 2 Trial Shows Dalantercept Has Limited Effectiveness in Ovarian Cancer Patients

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A Phase 2 clinical trial determined that treatment with dalantercept, an inhibitor of blood vessel maturation, is safe but has limited effectiveness in ovarian cancer patients, none of whom responded to the ... Read more

August 10, 2018

Collaboration Tests TRX518-Bavencio Combo in Phase 1/2 Trial of Solid Tumors

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Leap Therapeutics is launching a Phase 1/2 clinical trial to test its immunotherapy TRX518 in combination with Bavencio (avelumab) and chemotherapy in advanced solid tumors, as part of a collaboration established with Merck KGaA and Pfizer — the two ... Read more

August 8, 2018

Women Who Had Assisted Reproduction at Greater Risk of Ovarian, Breast Cancers, Study Says

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Women in the United Kingdom who had assisted reproduction are at greater risk of developing ovarian cancer and in situ breast cancer than the general population, a study found. But ... Read more

August 3, 2018

Adding TTFields to Taxol May Help Recurrent Ovarian Cancer Patients, Study Shows

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Adding Tumor Treating Fields (TTFields) — a therapy that uses electric fields to induce cell death — to weekly Taxol (paclitaxel) more than doubles the time to disease worsening or death in ovarian cancer patients ... Read more