Collaboration Tests TRX518-Bavencio Combo in Phase 1/2 Trial of Solid Tumors

Collaboration Tests TRX518-Bavencio Combo in Phase 1/2 Trial of Solid Tumors
Leap Therapeutics is launching a Phase 1/2 clinical trial to test its immunotherapy TRX518 in combination with Bavencio (avelumab) and chemotherapy in advanced solid tumors, as part of a collaboration established with Merck KGaA and Pfizer — the two companies developing and commercializing Bavencio. The trial is expected to begin recruiting patients in the first quarter of 2019. “The combination of TRX518 with anti-PD-L1 immunotherapy and cyclophosphamide has a solid scientific rationale and we look to build upon our early clinical and preclinical data highlighting the potential benefits of such a combination,” Cynthia Sirard, MD, vice president, Clinical Development of Leap Therapeutics, said in a press release. TRX518 is part of a new class of therapies, called immune checkpoint agonists, that amplify the immune system's response to cancer. The molecule is an antibody that binds the GITR receptor, but unlike other antibodies, which inhibit signaling, TRX518 is made to activate this receptor. Activation of GITR increases the production of pro-inflammatory molecules, reduces immunosuppression, and increases anti-cancer responses overall. This is thought to work well in combination with other cancer therapies, such as immune checkpoint inhib
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