Researchers Find Compounds that Kill Chemo-resistant Cancer Cells

Researchers Find Compounds that Kill Chemo-resistant Cancer Cells
A new study reports the development of compounds that could be used as ovarian cancer treatment. These compounds are particularly promising because they may be able to affect cancer that is resistant to chemotherapy. The study, "Exploring the Cytotoxicity, Uptake, Cellular Response, and Proteomics of Mono- and Dinuclear DNA Light-Switch Complexes," was published in Journal of the American Chemical Society. Chemotherapy remains the first line of treatment for many cancer types, including ovarian cancer, but resistance to chemotherapeutic drugs is a major problem. Some tumors have mutations that make them hard to kill with chemotherapy from the start. Others start off susceptible to chemotherapy but acquire resistance as the cancer cells adapt to the treatment. "Many cancer cells — about 20% — become resistant to common treatments by learning to ignore the internal signals that tell them to undergo programmed cell death, known as apoptosis," Jim Thomas, one of the authors of the study, said in a press release. The newly identified compounds kill cells without activating apoptosis, so the usual mechanisms of resistance don't work. The researchers tested their compounds against a panel of cell lines. The tested cells included normal, non-cancerous cells to determine whether the compounds would attack healthy cells, as well as cancer cells resistant and susceptible to chemotherapy, to test for anti-cancer activity. Two of the compounds — which have long, complicated chemical names — were effective at killing
Subscribe or to access all post and page content.

Leave a Comment

Your email address will not be published. Required fields are marked *