Docetaxel Nanoparticle CPC634 in Phase 2 Trial for Platinum-resistant OC

Docetaxel Nanoparticle CPC634 in Phase 2 Trial for Platinum-resistant OC
Cristal Therapeutics has begun patient dosing in its Phase 2a trial evaluating CPC634 — the chemotherapy docetaxel, delivered in nanoparticles — in patients whose ovarian cancer has become resistant to platinum-based chemotherapy. The exploratory study (2018-002117-36) is expected to include 27 patients across 10 clinical sites in the United Kingdom, Belgium, Netherlands, and Spain. Eligible participants received a maximum of three prior therapies for platinum-resistant disease, one of which could have included a taxane such as Taxotere (docetaxel). “Treatment of platinum-resistant ovarian cancer is an area of high unmet medical need and this trial will give us the opportunity to assess both the therapeutic efficacy of CPC634 and its potential to reduce toxic systemic side effects, such as neutropenia and alopecia seen with the current standard of care,” Jonathan Ledermann, MD, professor at UCL Cancer Institute, London, and principal investigator of the trial, said in a press release. CPC634, developed with Cristal’s proprietary CriPec technology, consists of tiny degradable particles that deliver the chemotherapy agent docetaxel specifically int
Subscribe or to access all post and page content.