New Sensor Detects Ovarian Cancer in Noninvasive Manner in Mice, Study Shows

New Sensor Detects Ovarian Cancer in Noninvasive Manner in Mice, Study Shows
A new sensor, found capable of identifying ovarian cancer in a noninvasive way in mice, may have the potential to detect early-stage ovarian cancer in the future, and possibly monitor for cancer recurrence. The technology is based on the detection of human epididymis protein 4 (HE4), one of the biomarkers approved by the U.S. Food and Drug Administration for detecting high-grade serous ovarian carcinoma (HGSC), the most frequent type of ovarian cancer. The study, “Noninvasive ovarian cancer biomarker detection via an optical nanosensor implant,” was published in the journal Science Advances. Ovarian cancer is frequently associated with poor outcomes, in part due to the advanced stage at which most cases are detected — at stage 3 or later in more than 60 percent of diagnoses — higher than any other form of cancer. The current screening methods, cancer antigen 125 testing and transvaginal ultrasounds, are
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