Antidepressant Use Does Not Increase Epithelial Ovarian Cancer Risk, Analysis Reveals

Antidepressant Use Does Not Increase Epithelial Ovarian Cancer Risk, Analysis Reveals
Women taking antidepressants are not at increased risk for epithelial ovarian cancer, according to a large-scale analysis of eight studies. While a combination of multiple studies is the best approach to determine an association, authors of the paper, "Association between antidepressant medication use and epithelial ovarian cancer risk: a systematic review and meta-analysis of observational studies," ask for future prospective studies to confirm their findings, which was published in the British Journal of Clinical Pharmacology. Most of the people taking antidepressants in the U.S. are women. A few studies have shown an association between certain classes of antidepressants and the development of tumors such as mammary tumors, fibrosarcoma, and melanoma in experimental animals. Although the mechanisms are still unclear, the effect seems to be mediated by hormonal imbalance as a result of the antidepressant treatments, resulting in a cancerous state. Other studies have suggested an opposite association, but the results are inconsistent overall, and there is need for comprehensive studies. Given that circumstance, researchers at the Shengjing Hospital of China Medical University aimed to evaluate the association between antidepressant use and epithelial ovarian cancer (EOC). The team analyzed data from published studies that had investigated the use of antidepressants and cancer from 1984 to August 2017. After filtering the studies, researchers ended up with eight published studies invo
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