Celsion to Present New Data from OVATION Trial at Ovarian Cancer Meeting

Celsion to Present New Data from OVATION Trial at Ovarian Cancer Meeting
All newly diagnosed ovarian cancer patients enrolled in the OVATION Phase 1b trial (NCT02480374) to date benefited from the addition of GEN-1 to standard of care, according to Celsion, the drug's developer. The new data, accepted for presentation at the American Association for Cancer Research (AACR) Addressing Critical Questions in Ovarian Cancer Research and Treatment Special Conference, Oct. 1-4 in Pittsburgh, shows that 100 percent of patients achieved at least stable disease and 86 percent saw a reduction in their tumors. Among those included in the highest dose level, all achieved a partial or complete response. Celsion's poster is titled "Immunological changes following intraperitoneal administration of a formulated IL-12 plasmid in combination with neoadjuvant chemotherapy in newly diagnosed advanced ovarian cancer patients," and will be presented by Dr. Khursheed Anwer, Celsion's executive vice president and chief scientific officer. GEN-1 is a lipid vesicle containing the DNA of the pro-inflammatory protein interleukin-12 (IL-12), leading to its sustained production and release specifically in the tumor site. IL-12 has shown relevant anti-cancer immunity by activating immune cells that kill tumor cells. By delivering IL-12 directly into cancer cells, GEN-1 avoids the adverse effects of increased inflammation in other areas of the body. GEN-1 has also generated promising early data as a monotherapy in patients with peritoneally metastasized ovarian cancer, and is being studied in combination with the anti-c
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