Lynparza Maintenance Reduces Risk of Disease Progression in Advanced Ovarian Cancer Patients, SOLO-2 Trial Shows

Lynparza Maintenance Reduces Risk of Disease Progression in Advanced Ovarian Cancer Patients, SOLO-2 Trial Shows
Women with BRCA-mutated relapsed ovarian cancer whose tumors responded to platinum-based chemotherapy took significantly longer to see their disease progressing when given AstraZeneca’s Lynparza (olaparib) as a maintenance therapy, compared to placebo. In addition to showing a 70 percent reduction in the risk of disease progression, the SOLO-2 Phase 3 trial (NCT01874353) revealed that Lynparza treatment did not reduce patients' quality of life, as reported by patients. The study, "Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial," was published in the journal Lancet Oncology. Lynparza belongs to a group of pharmaceuticals known as PARP inhibitors. It targets an enzyme, called PARP, which plays a role in repairing DNA errors in cells. The drug is particularly effective in cancers with mutations in other DNA-repairing genes, like BRCA 1 and BRCA2, which rely mainly on the PARP enzymes to counteract DNA damage. “Given the few treatment options available for patients with platinum-sensitive, relapsed ovarian cancer, the data for olaparib as maintenance therapy in SOLO2 are notable,” the authors stated. Lynparza was approved
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