Preventing Normal Cancer Cell Division Prompts Their Self-destruction, Study Reports

Preventing Normal Cancer Cell Division Prompts Their Self-destruction, Study Reports
Preventing cancer cells from dividing in the normal way may lead to their death, according to Israeli researchers who treated malignant cells with a compound that didn't affect normal cells. The treatment the Tel Aviv University team administered prevented the correct segregation of chromosomes to the daughter cells. Its inability to impact healthy cells meant it generated virtually no side effects. The study, which applies to ovarian and a number of other cancers, was titled "Exclusive destruction of mitotic spindles in human cancer cells." It was published in Oncotarget. "The discovery of an exclusive mechanism that kills cancer cells without impairing healthy cells, and the fact that this mechanism works on a variety of rapidly proliferating human cancer cells, is very exciting," Professor Malka Cohen-Armon of the university's Sackler School of Medicine, said in a press release. "According to the mechanism we discovered, the faster cancer cells proliferate, the faster and more efficiently they will be eradicated," said Cohen-Armon, the study's lead author. "The mechanism unleashed during mitosis may be suitable for treating aggressive cancers that are unaffected by traditional chemotherapy." The cytoskeletal structure that forms during cell division to distribute sister ch
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