PARP1

July 30, 2018

Loss of Certain Protein Identified in Ovarian Cancer Resistance to PARP Inhibitors

News

Researchers have identified a mechanism of resistance to PARP inhibitors — such as Lynparza (olaparib) and — in ovarian cancer, that involves the loss of a specific protein called 53BP1, according to ... Read more

May 14, 2018

Researchers Discover Mutations Behind Resistance to PARP Inhibitors Like Lynparza

News

Scientists have found mutations in the poly ADP-ribose polymerase (PARP) gene that cause resistance to PARP inhibitor therapies — such as Lynparza (olaparib) — in a mouse model and in one ... Read more