News

August 1, 2018

Zai Lab Starts Phase 3 Trial of ZL-2306 as First-Line Maintenance Therapy for Ovarian Cancer

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A Phase 3 clinical trial testing the investigational medication ZL-2306 (niraparib) as a maintenance therapy for ovarian cancer patients who are responding to their first-line chemotherapy has dosed its first ... Read more

July 30, 2018

Loss of Certain Protein Identified in Ovarian Cancer Resistance to PARP Inhibitors

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Researchers have identified a mechanism of resistance to PARP inhibitors — such as Lynparza (olaparib) and — in ovarian cancer, that involves the loss of a specific protein called 53BP1, according to ... Read more

July 27, 2018

Lynparza Maintenance for Ovarian Cancer Takes No Toll on Quality of Life, Study Shows

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Ovarian cancer patients who responded to platinum-based chemotherapy after failing at least one prior treatment may take Lynparza (olaparib) as maintenance therapy without worrying about their quality of life, a new study ... Read more

July 23, 2018

Post-diagnosis Use of Anti-Inflammatory Meds May Improve Ovarian Cancer-specific Survival, Study Suggests

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Regular use of anti-inflammatory medication, such as aspirin, after an ovarian cancer diagnosis appears to improve ovarian cancer-specific survival, a study shows. The study, “Pre-diagnosis and post-diagnosis use of common ... Read more

July 20, 2018

Phase 1/2 Trial Begins on ONCOS-102, Imfinzi Combination in Advanced Ovarian, Colorectal Cancers

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A new Phase 1/2 clinical trial has been launched testing a combination of investigational viral therapy ONCOS-102 and Imfinzi (durvalumab) in patients with advanced ovarian and colorectal cancers. The open-label trial ... Read more

July 16, 2018

Lynparza Maintenance Delays Disease Progression in Advanced Ovarian Cancer, Phase 3 Trial Shows

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Lynparza (olaparib), a PARP inhibitor, significantly prevents ovarian cancer from progressing or returning in women who responded to their first-line chemotherapy treatment, results from a Phase 3 trial show. The randomized, ... Read more

July 11, 2018

Artificial Ovary Might Help Women Conceive After Ovarian Cancer Treatment, Study Reports

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Researchers have developed a new technique for growing human ovarian follicles — the small fluid-filled sacs that give rise to mature eggs — on a bioengineered ovarian scaffold made of ... Read more

July 9, 2018

Kazia’s Cantrixil Shows Signs of Effectiveness in Advanced Ovarian Cancer Trial

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Cantrixil, an investigative therapy which targets cancer cells that cause recurrence, shows promise as a treatment for ovarian cancer patients who failed at least two prior therapies, according to Australia-based Kazia ... Read more

July 6, 2018

Basilea Begins Phase 2a Expansion Trial Testing BAL101553 in Ovarian, Brain Cancers

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Basilea Pharmaceutica has dosed its first patient in the expansion part of its Phase 1/2 trial (NCT02895360), which continues to explore the safety and effectiveness of BAL101553, an investigational tumor checkpoint controller, ... Read more

July 2, 2018July 2, 2018

Anti-cancer Protein, Once Reactivated, Seen to Target Ovarian Cancer Cells in Early Study

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Researchers have discovered how reactivating a protein called OPCML — a tumor suppressor molecule usually reduced or lost in cancer patients — works to suppress ovarian cancer cells. These findings ... Read more