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January 20, 2020January 20, 2020

Add-on NAMPT Inhibitor Prolonged Survival in Ovarian Cancer Mouse Model, Study Found

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Using standard platinum-based chemotherapy is often associated with the formation of unfavorable treatment-resistant cancer stem cells, which may ultimately contribute to cancer progression — but inhibiting an enzyme called NAMPT ... Read more

January 17, 2020

Large Study Finds No Strong Link Between Talc Powder and Ovarian Cancer Risk

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After decades of conflicting evidence about the possible link between talc powder in the genital area and ovarian cancer, the largest study conducted to date has found no strong connection ... Read more

January 16, 2020January 22, 2020

First Participant Dosed in Phase 1 Trial of Tmunity’s CAR T-cell Therapy in Solid Tumors

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The first participant has been dosed in a Phase 1 clinical trial evaluating Tmunity Therapeutics‘ CAR T-cell therapy, CART-TnMUC1, in people with certain solid tumors, including ovarian cancer, that are ... Read more

January 14, 2020February 21, 2020

FDA Reviewing Lynparza-bevacizumab as First-line Maintenance for Advanced Ovarian Cancer, Regardless of BRCA Status

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The U.S. Food and Drug Administration (FDA) has agreed to review AstraZeneca and Merck‘s request to extend the indication of oral Lynparza (olaparib) as a first-line maintenance therapy in combination with ... Read more

January 10, 2020January 10, 2020

Anixa and Moffitt Seek to Improve Potency of CAR T-cell Candidate for Ovarian Cancer

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Anixa Biosciences and Moffitt Cancer Center are seeking to develop a more potent version of their immunotherapy candidate for ovarian cancer, based on chimeric antigen receptor (CAR) T-cell technology, to ... Read more

January 8, 2020

Second Surgery for Recurrent Ovarian Cancer Does Not Improve Survival, Phase 3 Trial Shows

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A second surgery followed by chemotherapy is no better than chemotherapy alone at extending the lives of women with platinum-sensitive ovarian cancer who experienced disease recurrence after a first surgery. ... Read more

December 20, 2019

Trial Seeks Participants to Study AVB-500 Plus Imfinzi in Platinum-resistant Ovarian Cancers

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Aravive is recruiting participants for a Phase 1/2 clinical trial assessing a combination of its experimental treatment AVB-500 plus the immune checkpoint inhibitor Imfinzi (durvalumab) in women with platinum-resistant epithelial ... Read more

December 17, 2019January 21, 2020

Pivotal Trial of Mirvetuximab Soravtansine in Advanced Ovarian Cancer Levels Likely in 2020

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ImmunoGen is planning to open an open-label, pivotal clinical trial of mirvetuximab soravtansine in platinum-resistant ovarian cancer patients with high levels of the folate receptor alpha (FRα) protein early next year, ... Read more

December 13, 2019December 13, 2019

NICE Recommends Lynparza Tablets for Relapsed, BRCA-mutated Advanced Ovarian Cancers

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After an initial rejection due to cost-effectiveness concerns, the U.K.’s National Institute of Health and Care Excellence (NICE) has reversed its decision and is expanding the use of Lynparza (olaparib) tablets ... Read more

December 12, 2019January 6, 2020

Thin Mesh Loaded with CAR T-cells Seen to Shrink Inoperable Ovarian Tumors in Mice

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Implantable devices made of a thin metallic mesh loaded with cancer-fighting immune cells are able to shrink inoperable ovarian tumors in mice, offering a potential way to boost the efficacy ... Read more