Checkpoint Inhibitor CTX-2026 Shows Promising Efficacy in Preclinical Study

Checkpoint Inhibitor CTX-2026 Shows Promising Efficacy in Preclinical Study
Compass Therapeutics' CTX-2026, an antibody targeting the protein BTN3A1, could be therapeutic in ovarian cancer by helping the immune system destroy cancer cells, preclinical data show. The study, "BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells," was published in the journal Science. The body's immune system is responsible for fighting off infections and killing unhealthy cells, including cancer cells. Fundamentally, the immune system must be able to recognize and attack infected or cancerous cells while at the same time not attacking healthy cells. One of the strategies that has evolved to manage this dichotomy is immune checkpoints. Conceptually, checkpoints are biochemical systems for healthy cells to signal to immune cells that they are healthy and should not be destroyed. One of the best-studied checkpoint systems involves the protein PD-1. Cancer cells will often co-opt immune checkpoints to avoid being destroyed by the immune system. As such, therapies that block these checkpoints — such as PD-1 inhibitors — have shown great benefits in the treatment of cancer, since they allow the immune system to more effe
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