TCR2 Therapeutics has partnered with Raffit Hassan, MD, at the National Cancer Institute to test TC-210, a mesothelin-specific immunotherapy, in an ongoing Phase 1/2 clinical trial for people with advanced cancers that produce the mesothelin protein. Mesothelin is a protein highly abundant in several solid tumors, including ovarian cancer. Its abundance is linked with poorer prognosis, and is suggested to play a role in the development of certain tumors. While CAR T-cell therapy has shown exciting results for treating blood cancers, the response rates in solid cancer have been disappointing. That therapy consists of collecting a patient’s own T-cells and modifying them in the lab to produce a chimeric antigen receptor, or CAR, that targets a specific cancer protein. The CAR T cells are then given back to the patient by infusion. TCR2 Therapeutic’s TC-210 was designed with a new technology, called T-cell Receptor Fusion Constructs, or TRuC-T. It aims to harness the full potential of T-cells against cancer cells. In preclinical studies with cells and animal models of lung, ovarian and mesothelioma cancers, TC-210 showed robust anti-tumor activity. Moreover, T-cell activation and tumor clearance with TC-210 was faster than that achieved with CAR T-cell therapies targeting the mesothelin protein. The new treatment also appears safer than CAR T-cell therapies, exhibiting lower levels of cytokine release. This means that there was a lower systemic activation of the immune system, which can bring life-threatening consequences to patients. The ongoing Phase 1/2 trial (NCT03907852), which is recruiting patients in the U.S., is assessing the safety and efficacy of TC-210 in people with mesothelin-producing cancers who have been given prior chemotherapy.