Cancer Cells from Fallopian Tube Communicate with Healthy Ovaries to Promote Cancer Growth, Researchers Find

Cancer Cells from Fallopian Tube Communicate with Healthy Ovaries to Promote Cancer Growth, Researchers Find
Cancer cells from the fallopian tube — the precursors of ovarian cancer — communicate with healthy ovaries and trigger the release of a hormone called norepinephrine, creating an environment for the migration of cancer cells into the ovaries, Chicago researchers discovered. The study, “Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer,” was published in the journal ACS Central Science. Contrary to common belief, cells that cause ovarian cancer do not always originate in the ovaries. Recent evidence suggests that high-grade serous ovarian cancer (HGSOC) — the most malignant form of ovarian cancer — actually starts in the fallopian tube. "Over the last several years we have come to learn that ovarian cancer cells, specifically high-grade serous ovarian cancer cells, originate in the fallopian tube and migrate to the ovary, where they become established as ovarian cancer," Joanna Burdette, PhD, professor at the University of Illinois College of Pharmacy and the co-author of the paper, said in a press release. Communication between tumors and healthy cells in their vicinity is known to play an essential role in cancer development and progression. Small molecules help in this communication. However, this interaction and the players that regulate it are poorly understood in HGSOC. Researchers used imaging mass spectroscopy — an advanced technique that incorporates imaging methods to visualize the distribution of smal
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