Compounds Found to Reverse Chemotherapy Resistance in Ovarian Cancer in Lab Tests

Compounds Found to Reverse Chemotherapy Resistance in Ovarian Cancer in Lab Tests
A research team at Southern Methodist University (SMU) in Dallas, Texas, has identified three compounds that were able to reverse resistance to chemotherapy in ovarian tumors. In lab experiments based on calculations from a supercomputer at SMU, multi-drug-resistant ovarian cancer cells died when treated with common chemotherapies and the newly identified compounds. The discovery is important because the cells of some aggressive forms of cancer are resilient and often render chemotherapy ineffective. The study, “Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells,” appeared in the journal Scientific Reports. "Nature designs all cells with survival mechanisms, and cancer cells are no exception," Pia Vogel, director of the university’s Center for Drug Discovery, Design and Delivery, and one of two senior authors of the study, said in a press release. "So it was incredibly gratifying that we were able to identify molecules that can inhibit that mechanism in the cancer cells, thereby bolstering the effectiveness of chemotherapeutic drugs,” Vogel added. The mechanism the team explored is the most common way cancer cells become resistant to treatment. Many tumors have the ability to detect and fight off harmful substances with the help of pump proteins. These tumors react to cancer therapies, which must remain inside cells to kill a tumor, as they would with other harmful substances. The mechanism also is present i
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