Higher Levels of Tumor T-cells Predict Better Survival Rates in Certain Ovarian Cancer Patients, Study Finds

Higher Levels of Tumor T-cells Predict Better Survival Rates in Certain Ovarian Cancer Patients, Study Finds
The levels of certain white blood cells in tumors correlate with longer overall survival in patients with some types of epithelial ovarian cancer, regardless of first-line chemotherapy or the extent of residual disease, researchers have found. The study, "Dose-Response Association of CD8+ Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer," was published in the journal JAMA Oncology. A subset of white blood cell, known as CD8-positive tumor-infiltrating lymphocytes (TILs), can kill tumor cells after being activated by degraded proteins. Previous studies have shown that CD8-positive TILs are associated with a better prognosis for patients with epithelial ovarian cancer. Researchers from the Ovarian Tumor Tissue Analysis (OTA) Consortium aimed to clarify the details of this association. In the study, the levels of CD8-positive TILs were assessed in 5,577 patients with primary epithelial ovarian, peritoneal, or fallopia n tube cancer, including 3,196 with high-grade serous ovarian carcinomas (HGSOCs). The mean age at diagnosis was 58.4 years. The study showed an association between longer survival and increasing levels of CD8-positive TILs in HGSOCs. Indeed, while the median survival for patients with negative CD8-positive TILs was 2.8 years, those with high levels of these cells lived for a median of 5.1 years. This represented a 43 percent reduction in the risk of death, compared those with no dete
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