Organ-on-a-chip Device Shows How Cancer Cells Interact With Platelets to Drive Metastasis

Organ-on-a-chip Device Shows How Cancer Cells Interact With Platelets to Drive Metastasis
To communicate with platelets and start the process of cancer spread, ovarian cancer cells are able to break the barriers of blood vessels and let platelets inside the tumor environment, according to a study that used microfluidic organ-in-a-chip technology. Atorvastatin, a medication belonging to cholesterol-lowering statins, is able to maintain blood vessel integrity and prevent this interaction between cancer cells and platelets, potentially preventing cancer growth. The study, "OvCa-Chip microsystem recreates vascular endothelium–mediated platelet extravasation in ovarian cancer," was published in the journal Blood Advances. Interactions between cancer cells and platelets help drive metastasis of ovarian cancer, the process by which cancer spreads to other parts of the body. However, it was not previously known how ovarian cancer came into contact with platelets, prompting a team of researchers from Texas A&
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