Sutro’s Investigational Antibody-Drug Conjugate Shows Promise in Advanced Ovarian Cancer Phase 1 Trial

Sutro’s Investigational Antibody-Drug Conjugate Shows Promise in Advanced Ovarian Cancer Phase 1 Trial
STRO-002, an investigational antibody-drug conjugate being developed by Sutro Biopharma, is safe and shows promising efficacy in women with advanced ovarian, fallopian tube, or primary peritoneal cancer, early Phase 1 clinical data show. The findings were presented during the recent AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference 2019 in Boston, in the poster “Antitumor activity of STRO-002, a novel anti-folate receptor-α (FRα) antibody drug conjugate (ADC), in patient-derived xenograft (PDX) models and preliminary Phase I dose escalation safety outcomes in patients with ovarian carcinoma (OC).” An estimated 80% of ovarian cancers have high levels of the folate receptor alpha (FRα) protein. STRO-002 is an antibody-drug conjugate that specifically targets FRα. Once the antibody binds to a cell positive for FRα, it releases a toxic compound, killing the cancer cell without harming healthy cells. In a mouse model of endometrial cancer, where FRα is also produced in excess, treatment with STRO-002 significantly inhibited tumor growth, with the extent of its effects being mostly dependent on the FRα levels within tumor cells. While the treatment had no effect in cancer cells lacking the receptor, it significantly inhibited tumor growth in four of six models with very high levels of FRα, the researchers showed. In models with low and medium FRα levels, STRO-002 also had some anti-cancer activit
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