Maintenance treatment with Zejula (niraparib) prolongs the time lived without disease worsening in women with newly diagnosed advanced ovarian cancer who are responding to their first-line platinum-based chemotherapy — regardless of mutations in DNA repair genes — a Phase 3 clinical trial has shown. Patients treated with Zejula lived a median of 5.6 months more compared with those receiving a placebo. The therapy led to an even greater benefit – a median lengthening of 11.5 months – in women who had tumors defective in DNA repair, a status termed "homologous recombination deficiency" (HRD). GSK, the owner of Zejula, plans to use this data to ask for an extension of the therapy's approved indication by the end of 2019. The trial results were presented Sept. 28 at the European Society for Medical Oncology (ESMO) 2019 congress, held in Barcelona, Spain, and simultaneously made available in a more detailed report "Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer," published in the journal New England Journal of Medicine.