Adding Veliparib Extends Time Without Disease Progression in Metastatic Ovarian Cancer, Phase 3 Trial Finds

Adding Veliparib Extends Time Without Disease Progression in Metastatic Ovarian Cancer, Phase 3 Trial Finds
Using veliparib in combination with chemotherapy as first-line and then maintenance therapy post-surgery significantly extended the time without disease progression in women with newly diagnosed metastatic high-grade serous (HGS) ovarian cancer, according to Phase 3 trial results. The research was presented in the session, “VELIA/GOG-3005: Integration of veliparib (V) with front-line chemotherapy and maintenance in women with high-grade serous carcinoma of ovarian, fallopian tube or primary peritoneal origin HGSC,” at the 2019 European Society for Medical Oncology (ESMO) Congress and published in the New England Journal of Medicine. Veliparib is an investigational PARP enzyme inhibitor developed by AbbVie. It is designed to prevent cancer cells from repairing DNA errors and thereby cause their death. The international, AbbVie-sponsored VELIA Phase 3 trial (NCT02470585) assessed the potential benefits of adding veliparib to standard chemotherapy with carboplatin and Taxol (paclitaxel) — and as maintenance therapy — for patients with stage III or IV HGS epithelial ovarian, fallopian tube, or primary peritoneal cancer. "This is the first clinical trial to use a PARP inhibitor combined with chemotherapy for newly diagnosed ovarian cancer patients," Robert L. Coleman, MD, the study’s lead investigator and a professor at The University of Texas MD Anderson Cancer Center, said in a news release. "The patient population enrolled in the trial were reflective of those we see in clinic every day as it allowed for both stage III and stage IV patients and those getting primary surgery or those undergoing neoadjuvant chemotherapy before surgery," he added. From July 2015 and July 2017, a total of 1,140 participants were randomly assigned to this treatment
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