Phase 3 Trial Launched to Test TTFields-Taxol Combo on Platinum-resistant Ovarian Cancer

Phase 3 Trial Launched to Test TTFields-Taxol Combo on Platinum-resistant Ovarian Cancer
Novocure has initiated a Phase 3 trial investigating its Tumor Treating Fields (TTFields) — a method that uses electric fields to disrupt cell division — in combination with Taxol (paclitaxel) as a treatment for ovarian cancer patients who are resistant to platinum-based chemotherapy. The trial — which is for women who received up to two prior lines of therapy after developing resistance to platinum-based chemotherapy — comes after promising findings from the INNOVATE Phase 2 trial (NCT02244502), where the combination more than doubled the time patients lived without disease worsening, compared with historical controls treated with Taxol alone. Ovarian cancer, a disease that affects 22,500 women every year in the U.S., is often treated with a chemotherapy regimen containing a platinum agent, such as cisplatin or carboplatin. However, while most patients respond, the majority will see their cancer return or progress within a few months. These patients — platinum-resistant ovarian cancer patients — have numerous therapies available, but survival rates are low. “Ovarian cancer is one of the most aggressive forms of cancer,” Ignace Vergote, chairm
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