Uterine Fluid Analysis May Aid in Early Diagnosis of Aggressive OC

Uterine Fluid Analysis May Aid in Early Diagnosis of Aggressive OC
Proteomic analysis — the characterization of all proteins present in a cell at a given time — in liquid biopsies from the womb may facilitate the early diagnosis of women who are genetically predisposed to develop high-grade ovarian cancer (HGOC), a study says. The study, "Microvesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection," was published in Molecular & Cellular Proteomics. HGOC is the most aggressive type of ovarian cancer and is responsible for approximately 70% of all cases worldwide. Its poor prognosis and high mortality rates are directly linked to the stage at which it is first diagnosed: while patients at early stages of the disease have more than a 90% chance of surviving the next five years after diagnosis, those diagnosed at later stages, when the cancer has already spread, have much lower chances. "Regrettably, [approximately] 75% of HGOC cases are diagnosed at late stage regardless of adherence to testing recommendations. This grim reality stems primarily from the lack of effective screening methods and of early-stage biomarkers," the investigators saidf. "If we could change this reality by detecting (ovarian cancer) at a curable stage, we could save many lives," Keren Levanon, a physician-researcher at Chaim Sheba Medical Center in Israel and corresponding author of the study, said in a press release. In an attempt to develop a new diagnostic test that could be used to detect early signs of HGOC, researchers led by Levanon and Tamar Geiger of Tel Aviv University used proteomic analysis in liquid biopsies from the womb to look for cancer signatures. Because body fluids contain many proteins that can mask the presence of other cancer-related proteins, scientists decided to perform the proteom
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