Uterine Fluid Analysis May Aid in Early Diagnosis of Aggressive OC

Uterine Fluid Analysis May Aid in Early Diagnosis of Aggressive OC
Proteomic analysis — the characterization of all proteins present in a cell at a given time — in liquid biopsies from the womb may facilitate the early diagnosis of women who are genetically predisposed to develop high-grade ovarian cancer (HGOC), a study says. The study, "Microvesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection," was published in Molecular & Cellular Proteomics. HGOC is the most aggressive type of ovarian cancer and is responsible for approximately 70% of all cases worldwide. Its poor prognosis and high mortality rates are directly linked to the stage at which it is first diagnosed: while patients at early stages of the disease have more than a 90% chance of surviving the next five years after diagnosis, those diagnosed at later stages, when the cancer has already spread, have much lower chances. "Regrettably, [approximately] 75% of HGOC cases are diagnosed at late stage regardless of adherence to testing recommendations. This grim reality stems primarily from the lack of effective screening methods and of early-stage biomarkers," the investigators saidf. "If we could change this reality by detecting (ovarian cancer) at a curable stage, we could save many lives," Keren Levanon, a physician-researcher at Chaim Sheba Medical Center in Israel and corresponding author of the study, said in a
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