Phase 2 Trial Completes Dosing First OC Patient with Aivita’s Cell Therapy

Phase 2 Trial Completes Dosing First OC Patient with Aivita’s Cell Therapy
A Phase 2 trial exploring Aivita Biomedical’s cell therapy AVOVA-1 for ovarian cancer has treated its first patient and continues to recruit participants across eight sites in the United States. So far, 11 patients have been included in the study, including one who received the planned eight treatment sessions, under the supervision of Lisa Abaid, MD, principal investigator at Gynecologic Oncology Associates in Newport Beach, California. Aivita's immunotherapy uses a patient’s own dendritic cells, which are boosted to fight the tumor. Dendritic cells are a type of immune cell that teaches T cells what is foreign and abnormal and should be targeted for destruction. Aivita’s researchers develop AVOVA-1 by joining a patient’s dendritic and tumor cells in the lab, making the dendritic cells present cancer-specific proteins at their surface. When injected back into the patient, these will re-educate the T cells to react against any cancer cell they encounter. With this approach, researchers believe they can target tumor-initiating cells — those responsible for cancer growth, spreading, and disease relapse — in a more efficient manner than when dendritic cells carrying only some tumor proteins are used. The Root Of Cancer trial (NCT02033616) is expected to enroll about 99 patients with advanced ovarian, fallopian tube, or primary peritoneal cancer. To be eligible, patien
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