Bacterial Toxin-based Test Could Help Detect Ovarian Cancer Early

Bacterial Toxin-based Test Could Help Detect Ovarian Cancer Early
A bacterial toxin-based blood test could help in the early detection of ovarian cancer, and function as a tool for monitoring treatment and disease progression in patients with advanced disease, a study shows. The study, "Detection of N-glycolylneuraminic acid biomarkers in sera from patients with ovarian cancer using an engineered N-glycolylneuraminic acid-specific lectin SubB2M," was published in Biomedical and Biophysical Research Communications. The survival rate for patients diagnosed with early-stage ovarian cancer is over 90%, but because this cancer is usually asymptomatic at first, diagnoses often aren't made until the disease has progressed past the early stage. Therefore, new tests that can detect early-stage ovarian cancer are needed. “Ovarian cancer is notoriously difficult to detect in its early stages, when there are more options for treatment and survival rates are better. Our new test is therefore a potential game-changer,” professor James Paton, director of the University of Adelaide (Australia) Research Centre for Infectious Diseases, where the study was performed, said in a press release. The team was particularly interested in a protein called human cancer antigen 125 (CA125). Most ovarian cancer patients have elevated levels of CA125 in their blood when they are diagnosed, but the protein is also elevated in
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