Long Non-coding RNAs Found Linked to Ovarian Cancer Metastasis, Study Shows

Long Non-coding RNAs Found Linked to Ovarian Cancer Metastasis, Study Shows
Researchers have found a set of long non-coding RNAs (lncRNAs) – RNA molecules with no protein-coding capacity – that participate in the metastatic process of ovarian cancer cells. Inhibiting one of these molecules, called DNM3OS, reduced migration and invasion, suggesting that targeting lncRNAs might be a viable approach for treating ovarian cancer. The study, “Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition,” was published in the journal Nature Communications. Metastasis, which refers to the spread of cancer cells, is a common occurrence in patients with ovarian cancer and occurs in as many as 80 percent of patients. Metastasis is dependent on the ability of cancer cells to undergo a process called epithelial-to-mesenchymal transition (EMT), which allows cells to detach from other cancer cells and enter circulation. Recent studies have suggested that lncRNAs are involved in the metastatic process. These molecules are known to regulate gene expression, though the exact mechanism by which this occurs is unknown. Researchers set out to determine whether lncRNAs were involved in ovarian cancer metastasis, and if so, which ones were involved. After conducting a bioinformatics analysis of more than 700 ovarian cancer molecular profiles, the team found three lncRNAs whose levels were significantly higher in aggressive ovarian cancer samples. The lncRNAs, called DNM3OS, MEG3, and MIAT, regulate genes involve
Subscribe or to access all post and page content.