Siamab’s Antibody-drug Conjugates for Ovarian Cancer Seen to Succeed in Animal Models

Siamab’s Antibody-drug Conjugates for Ovarian Cancer Seen to Succeed in Animal Models
Siamab Therapeutics’ preclinical work with anti-STn antibody-drug conjugates is moving forward, and in animal models — including primates — it showed the conjugates could safely and effectively treat ovarian cancer resistant to chemotherapy. The treatment blocked tumor progression in all models tested, in which scientists injected patient-derived or lab-grown ovarian cancer cells into mice. Researchers underscored that they observed complete tumor eradication in some treatment groups. The research team, working with colleagues at Harvard Medical School, presented study updates at the 2017 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Philadelphia two weeks ago. Their poster, “Humanized anti-Sialyl-Tn monoclonal antibody-drug conjugates inhibit tumor growth in vitro and in vivo,” also showed that the levels of STn in these tumors were lowered, indicating that the drugs were specific to their targets. “Our lead ST1 program shows compelling efficacy and safety across a range of PDX [patient-derived xenograft — a xenograft is transplant of tissue between species] and xenograft studies, underscoring the promise of our anti-STn antibody approach to treating chemoresistant solid tumors,” Jeff Behrens, president and chief executive officer of Siamab, said in a press release. In addi
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Magdalena holds an MSc in Pharmaceutical Bioscience and an interdisciplinary PhD merging the fields of psychiatry, immunology and neuropharmacology. Her previous research focused on metabolic and immunologic changes in psychotic disorders. She is now focusing on science writing, allowing her to culture her passion for medical science and human health.

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