BRCA1 and BRCA2 Mutations Increase Risk for Breast, Ovarian Cancers, Study Finds

BRCA1 and BRCA2 Mutations Increase Risk for Breast, Ovarian Cancers, Study Finds
Women who carry BRAC1 or BRAC2 genetic mutations have an increased risk of developing breast and ovarian cancers, according to a recent report published in JAMA. The study, “Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers,” may help doctors identify patients more likely to develop these diseases and design monitoring programs for them. Alterations in BRCA1 or BRCA2 gene sequences are known to be associated with the development, progression, and aggressiveness of breast and ovarian cancers. Researchers at the University of Cambridge, in collaboration with the BRCA1 and BRCA2 Cohort Consortium, assessed the age-specific risk of breast or ovarian cancer for women carrying BRCA1 or BRCA2 mutations. The research included women from the International BRCA1/2 Carrier Cohort Study, the Breast Cancer Family Registry, and the Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer. A total of 9,856 participants, including 6,036 BRCA1 and 3,820 BRCA2 carriers were evaluated. At the start of the study, 5,046 participants were cancer-free, and 4,810 had breast or ovarian cancer, or both. After a median follow-up of five years, researchers found that those carrying BRCA1 and BRCA2 mutations had a 72% and 69% higher risk, respectively, of developing breast cancer by the age of 80. The incidence of breast cancer was seen to increase rapidly until the age range of 30 to 40 for BRCA1 carriers, and 40 to 50 for BRCA2 carriers. After that, the incidence remained st
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