Oregovomab Combo Benefits Ovarian Cancers More Than Chemo Alone, Study Reports

Oregovomab Combo Benefits Ovarian Cancers More Than Chemo Alone, Study Reports
Adding oregovomab to standard chemotherapy significantly increases the time it takes for a newly diagnosed advanced ovarian cancer patient to have their disease progress or die, according to a Phase 3 clinical trial. OncoQuest, which developed oregovomab, will report the preliminary results of the trial at the American Society of Clinical Oncology meeting in Chicago next month. Its poster-session presentation on June 3 will be titled "A randomized phase II study assessing an optimized schedule of oregovomab (O) anti-CA125 vaccination with carboplatin paclitaxel (CP) relative to CP alone in front-line treatment of optimally cytoreduced stage III/IV ovarian cancer (EOC)." Oregovomab is an antibody that fights CA125, a protein expressed at the surface of ovarian cancer cells. By targeting the protein, oregovomab helps immune cells recognize and attack cancer cells. "We are pleased to share these initial results from our phase 2 study evaluating our lead drug, oregovomab, an anti-CA125 murine monoclonal antibody in scheduled combination with standard of care chemotherapy (carboplatin and paclitaxel) compared to standard of care alone in ovarian cancer patients in the front-line or initial treatment setting," Madi Madiyalakan, OncoQuest’s CEO, said in a news release. The trial (
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