New Compound May Be Able to Fight Chemoresistant Ovarian Cancer Cells

New Compound May Be Able to Fight Chemoresistant Ovarian Cancer Cells
Scientists at the Moscow Institute of Physics and Technology (MIPT) have synthesized a molecule that may be able to fight chemoresistant ovarian cancer, according to a study recently published in the the European Journal of Medicinal Chemistry. The molecule, which was described in the study, "Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies," may be helpful in the treatment of ovarian cancer patients whose disease recurred following chemotherapy. The researchers developed 37 different compounds belonging to a class known as aminoisothiazoles which are used in a wide range of pharmacological and biological applications, and assessed their anti-tumor properties. "We made the decision to experiment with aminoisothiazoles because compounds of this class exhibit a diverse range of pharmacological and biological activities. This led us to expect that with the appropriate functional groups, they might act as anticancer agents," Alexander Kiselyov said in a press release. The compounds were developed through a straightforward approach that involved six steps, and which used standard, easily obtainable reagents. Then the researchers tested each compound on human cancer cell lines from breast adenocarc
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