BRCA1 Gene Mutations Increase Risk of Developing Aggressive Uterine Cancer, Study Reveals

BRCA1 Gene Mutations Increase Risk of Developing Aggressive Uterine Cancer, Study Reveals
Women who carry the BRCA1 gene mutation are known to be at higher risk for breast and ovarian cancer. Now, researchers at Duke Cancer Institute have shown that the risk for an aggressive form of uterine cancer is also increased in these women, revealing that hysterectomy, the surgical removal of the uterus, should be considered a treatment option. The study "Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations," was published in the journal JAMA Oncology. Women with the BRCA1 gene mutation often have preventive surgeries to remove both breasts, as well as their ovaries and fallopian tubes. But the need to remove the uterus has been a controversial topic due to conflicting evidence. Although small studies have identified an association between BRCA1 mutation and uterine cancer, larger studies were needed to understand whether hysterectomy should be standard treatment for women with this mutation. “This is the study that has been needed,” lead author Noah D. Kauff, MD, who leads the Clinical Cancer Genetics Program at the Duke Cancer Institute, said in a press release. “Our study presents the strongest evidence to date that women with this genetic mutation should at least discuss with their doctors the option of having a hysterectomy along with removal of their ovaries and fallopian tubes.” Researchers examined 1,083 women from nine
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